Which manifestation is associated with loop diuretic use?

• A. Weak, irregular pulse and poor muscle tone
• B. Restlessness and agitation
• C. Paresthesias and irritability
• D. Increased blood pressure and muscle spasms

Answer: (A)

Loop diuretics promote loss of potassium along with sodium and water, which often leads to hypokalemia. Potassium is crucial for maintaining normal heart rhythm and muscle function. When potassium drops, you can see a weak, irregular pulse from potential arrhythmias and general muscle weakness or reduced tone. That combination—cardiac rhythm changes plus neuromuscular weakness—fits the effects of loop diuretics best. The other options describe symptoms more typical of CNS agitation, sensory disturbances, or hypertension with cramps, which aren’t the hallmark effects of loop diuretic–induced electrolyte changes.