Which action would the nurse take first if an allergic reaction to a blood transfusion occurs?

• A. Shut off the infusion.
• B. Slow the rate of flow.
• C. Administer an antihistamine.
• D. Call the health care provider (HCP).

Answer: (A)

The main action is to stop the transfusion immediately. Halting the infusion prevents more donor antigen and reaction mediators from entering the patient, which is the fastest way to stop the progression of the reaction and protect the airway, breathing, and circulation. After the transfusion is stopped, the nurse should assess the patient’s vital signs and overall status, keep the IV line open with normal saline if ordered, and follow facility protocol, which typically includes notifying the healthcare provider and starting appropriate treatment (such as antihistamines or other meds) once orders are in place. Slowing the rate would continue exposure and isn’t effective as the first move, and calling the provider without stopping the transfusion delays critical stabilization.