When a transfusion reaction is suspected, what is the essential initial action?

• A. Continue transfusion with slower rate
• B. Stop transfusion and report
• C. Administer acetaminophen
• D. Flush IV with saline only

Answer: (B)

When a transfusion reaction is suspected, the immediate action is to stop the transfusion right away and report the event to the treating physician and the blood bank. This halts further exposure to the donor product, which could be incompatible or contaminated, and reduces the risk of the reaction worsening. After stopping, keep the IV line open with normal saline to maintain circulation and to facilitate further treatment if needed, and notify the medical team so they can assess, order labs, and begin appropriate interventions. Preserve the transfusion materials and collect samples as instructed for investigation. Do not attempt to continue the transfusion or give medications to mask symptoms without medical guidance.