When a norepinephrine infusion is prescribed for a client in septic shock, which intravenous line would be the most appropriate for the infusion?

• A. Implanted port
• B. Midline catheter
• C. 18-gauge peripheral venous catheter
• D. Peripherally inserted central catheter (PICC) line

Answer: (D)

Vasopressor therapy with norepinephrine requires central venous access to minimize tissue injury from extravasation and ensure reliable, continuous infusion. A central line lets the drug mix quickly with the central blood volume and reduces the risk of severe damage if a leak occurs. A PICC line provides central access with the catheter tip in the superior vena cava, making it appropriate for sustained vasopressor infusions in septic shock. In contrast, a midline catheter stays in peripheral veins and doesn’t reach the central circulation, increasing extravasation risk; a standard peripheral IV line has the highest risk of infiltration and is not suitable for norepinephrine; an implanted port is designed for long-term outpatient therapy and isn’t ideal for the urgent, continuous central dosing needed in septic shock.